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Pre-Implantation Genetic Diagnosis (PGD)

Caring for Every Stage of Womanhood

Pre-Implantation Genetic Diagnosis (PGD) – Advanced IVF Genetic Testing for Healthy Babies

When planning a family through IVF, ensuring that embryos are free from serious inherited conditions is a top priority. Pre-implantation Genetic Diagnosis (PGD) is an advanced form of IVF genetic testing that allows doctors to identify embryos carrying specific genetic or chromosomal abnormalities before they are transferred to the uterus. By selecting only healthy embryos, PGD significantly improves the chance of a successful pregnancy and the birth of a healthy baby.
Pre-implantation Genetic Diagnosis is a laboratory procedure performed during an in vitro fertilization (IVF) cycle. After fertilization, embryos are cultured for several days until they reach the blastocyst stage. At this point, a few cells are carefully removed from the embryo’s outer layer for detailed genetic analysis.
Unlike routine embryo grading, which evaluates appearance, PGD provides a clear genetic picture of the embryo. The test detects single-gene disorders, chromosomal rearrangements, and other abnormalities that might lead to miscarriage, failed implantation, or inherited disease.

How PGD Testing Works in IVF

Step 1: IVF and Embryo Development

The process begins with a standard IVF cycle. Eggs are retrieved from the ovaries and fertilized with sperm in a controlled laboratory environment. The embryos are then cultured for five to six days until they reach the blastocyst stage.

Step 2: Embryo Biopsy

At the blastocyst stage, an embryologist uses precision micromanipulation techniques to remove a few cells from the trophectoderm, the outer layer destined to form the placenta. This procedure is safe and does not harm the inner cell mass that develops into the baby.

Step 3: Genetic Analysis

The sampled cells undergo advanced genetic testing to detect:

  • Single-gene disorders (PGT-M) – such as cystic fibrosis, sickle cell anemia, or thalassemia.

  • Chromosomal rearrangements (PGT-SR) – including translocations or inversions that can cause miscarriages.

  • Aneuploidy screening (PGT-A) – checking for extra or missing chromosomes linked to conditions like Down syndrome.

Step 4: Embryo Transfer

Only embryos that test genetically normal are selected for transfer, giving couples the best chance of a healthy pregnancy.

Key Benefits of Pre-Implantation Genetic Diagnosis

Choosing PGD as part of your IVF journey offers many advantages:

  • Prevents Inherited Disorders – Identifies embryos carrying known genetic conditions.

  • Improves IVF Success Rates – Transfers only genetically healthy embryos, increasing implantation chances.

  • Reduces Miscarriage Risk – Minimizes pregnancy loss caused by chromosomal abnormalities.

  • Supports Family Planning – Helps couples with a history of genetic disease make informed reproductive choices.

  • Saves Time and Emotional Stress – Fewer failed IVF cycles mean faster time to a successful pregnancy.

Who Should Consider PGD Testing

While PGD can benefit many IVF patients, it is especially recommended for:

  • Couples with a known family history of genetic disorders.

  • Women of advanced maternal age (35 years and above).

  • Couples with a history of recurrent miscarriages.

  • Patients with repeated IVF failures despite healthy-appearing embryos.

  • Individuals carrying chromosomal translocations or structural abnormalities.

Your fertility specialist will review your medical and family history to determine whether PGD testing is right for you.

Success Rates and Safety of PGD

Modern PGD techniques are safe and highly reliable. By removing only a few trophectoderm cells, the biopsy does not damage the embryo’s ability to implant or develop normally.

Clinical studies consistently show that transferring genetically screened embryos leads to higher implantation rates, improved live birth rates, and lower miscarriage rates compared to conventional IVF.

Why Choose Avni Women’s Hospital for Pre-Implantation Genetic Diagnosis

Experienced IVF & Genetics Team

At Avni Women’s Hospital, our fertility specialists, led by Dr. Hema Reddy, combine more than 25 years of expertise with advanced training in reproductive genetics. Our team carefully guides each couple through the PGD process with compassion and precision.

State-of-the-Art Laboratory

Our world-class IVF lab is equipped with advanced micromanipulation systems, time-lapse incubators, and next-generation sequencing technology for accurate genetic analysis.

Proven Results

With thousands of successful IVF cycles and healthy births, Avni Women’s Hospital has earned a reputation for excellence in pre-implantation genetic testing and fertility care.

Frequently Asked Questions About PGD

Yes. Only a few cells from the outer layer of the embryo are tested, leaving the part that develops into the baby unharmed.

PGD greatly reduces the risk of passing on genetic disorders but cannot rule out all conditions. Regular prenatal care remains essential.

Genetic analysis typically takes five to seven days. Embryos are frozen during this time and transferred in a later cycle.

Costs vary depending on the number of embryos tested and the complexity of the genetic analysis. Our team provides a detailed cost estimate during consultation.

PGD can identify sex chromosomes, which may help avoid sex-linked diseases where legally permitted.

Take the Next Step Toward a Healthy Family

Starting a family is one of life’s most exciting journeys, and Pre-implantation Genetic Diagnosis can provide the peace of mind that your baby begins life free from serious inherited conditions.

Schedule a consultation with the fertility specialists at Avni Women’s Hospital today to learn how PGD testing can increase your chances of a healthy pregnancy and a healthy baby.

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+91 9856463333

Kompally , secunderabad

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