DNA fragmentation index (DFI)
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DNA fragmentation index (DFI)
DNA Fragmentation Index (DFI):
The DNA Fragmentation Index (DFI) is a test that assesses the integrity of DNA in sperm cells. Healthy sperm DNA is crucial for successful fertilization and embryo development. Damaged DNA can lead to:
Reduced fertilization rates
Increased miscarriage risk
Chromosomal abnormalities in offspring
How does DFI work?
The test measures the percentage of sperm with fragmented DNA using various techniques. A lower DFI indicates better sperm DNA quality. Different thresholds are used depending on the specific test and lab, but generally
Who should consider DFI testing?
Couples experiencing fertility issues: Unexplained infertility, recurrent miscarriages, failed IVF cycles.
Men with known risk factors: Varicocele (enlarged veins), infections, environmental toxins.
Couples planning assisted reproductive technologies (ART): IVF, ICSI.
DFI does not guarantee fertility success, but it provides valuable information about sperm health and can guide treatment decisions. Consult a healthcare professional for personalized advice and interpretation of your DFI results.
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