DNA Fragmentation Index (DFI):

The DNA Fragmentation Index (DFI) is a test that assesses the integrity of DNA in sperm cells. Healthy sperm DNA is crucial for successful fertilization and embryo development. Damaged DNA can lead to:

Reduced fertilization rates

Increased miscarriage risk

Chromosomal abnormalities in offspring

How does DFI work?

The test measures the percentage of sperm with fragmented DNA using various techniques. A lower DFI indicates better sperm DNA quality. Different thresholds are used depending on the specific test and lab, but generally:

DFI < 30%: Good sperm quality

DFI 30-50%: Moderate fragmentation, may impact fertility

DFI > 50%: Significant fragmentation, likely affecting fertility

Who should consider DFI testing?

Couples experiencing fertility issues: Unexplained infertility, recurrent miscarriages, failed IVF cycles.

Men with known risk factors: Varicocele (enlarged veins), infections, environmental toxins.

Couples planning assisted reproductive technologies (ART): IVF, ICSI.

DFI does not guarantee fertility success, but it provides valuable information about sperm health and can guide treatment decisions. Consult a healthcare professional for personalized advice and interpretation of your DFI results.

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